Linking pore and pole

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Linking pore and pole

Extra exocytosis rescues polarity hang et al. (page 273) report a link between the exocyst and the t-SNAREs used for vesicle–plasma membrane fusion. The link comes in the form of Sro7p and Sro77p. These are yeast homologues of lethal giant larvae (Lgl), which was already known to bind t-SNAREs. Lgl is required for cell polarity and binds directly to t-SNAREs. Mutating Lgl induces polarity defec...

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Saccharomyces cerevisiae Ndc1p Is a Shared Component of Nuclear Pore Complexes and Spindle Pole Bodies

We report a novel connection between nuclear pore complexes (NPCs) and spindle pole bodies (SPBs) revealed by our studies of the Saccharomyces cerevisiae NDC1 gene. Although both NPCs and SPBs are embedded in the nuclear envelope (NE) in yeast, their known functions are quite distinct. Previous work demonstrated that NDC1 function is required for proper SPB duplication (Winey, M., M.A. Hoyt, C....

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Nuclear envelope insertion of spindle pole bodies and nuclear pore complexes

The defining feature of eukaryotic cells is the double lipid bilayer of the nuclear envelope (NE) that serves as a physical barrier separating the genome from the cytosol. Nuclear pore complexes (NPCs) are embedded in the NE to facilitate transport of proteins and other macromolecules into and out of the nucleus. In fungi and early embryos where the NE does not completely breakdown during mitos...

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Background and objective: Most higher education curricula do not provide the competencies graduates need in the occupational fields, resulting in waste of money and lower effectiveness while increasing the number of unemployed graduates. Competency-based education is an innovative educational model that can solve such problems and lead education activists to design competency-based curricula. T...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2005

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb1702iti1